The objective of the study was to evaluate the reaction of Theobroma cacao clones to the artificial inoculation of Moniliophthora roreri, at the Tulumayo Experimental Station, Tingo María. Eleven “S” clonal hybrids and 3 “C” farmer collection clones were studied. Conidia of M. roreri were inoculated into 65-day-old fruits, protected for 48 h in a humid chamber. Incidence, external severity (SE) according to fruit damage in degrees were evaluated weekly, 0: healthy fruit, 1: hydrosis, 2: swelling, 3: necrosis, 4: mycelium that covers ¼ part of the stain and 5: mycelium that covers more than ¼ part of the stain, and internal severity (SI): percentage of necrotic grain in each fruit, the clones being compared by ANOVA and Tukey’s test (α = 0.05). The results show a high incidence in all the clones, with values of 91.67 to 100%. Clone S-19 showed the lowest SE, which was 2.64, ...