There is a growing demand for increasingly biocompatible materials, especially for pulp therapies in children. In today's market, biomaterials such as mineral trioxide aggregate (MTA) and Biodentine have demonstrated high bioactive properties. However, no material has yet been identified that optimally meets all clinical requirements, due to factors such as biocompatibility, pulp repair potential, among others. The objective of this literature review was to determine the clinical and radiographic success rate of bioactive materials in pulpotomies, compared to the use of conventional materials. Additionally, the preferred final restorative material used after the application of the bioactive material was identified. PubMed, Scopus, ScienceDirect, Virtual Health Library, EBSCOHost, and ProQuest databases were used. The search included publications up to May 25, 2024, following PRISMA guide...