This research was conducted in the field Horticultural Jorge Pelaez Ing in Fencing Munich district, district and province of Lamas, San Martin region, Peru.; at South latitude 06 ° 20'15 "West Longitude 76 ° 30 '5" and 920 m altitude. s. n. m. m .; e! to determine the toxic effect and efficiency of protectant and systemic fungicides formulated alone or in mixtures for handling pathogenic fungi that cause leaf diseases in tomato variety Rio Grande and make economic analysis of tomato production with each Treatments. Before applying fungicides samples of the tomato leaf is transported, the Plant Health Laboratory of the University, for analysis and taxonomic keys using the following pathogens were identified. Stemphytlium sp, Pftytophthora sp. and Botrytis sp. Fungicides were applied to tomato plants after 10 days transplanted to the field, under the Complete Block design) with 11 treatm...