Background: Resilience is a psychological resource related to significant improvements in the health of people with type 2 diabetes mellitus T2DM and is linked to religious coping and spirituality and lower levels of stress. Objectives: To analyze the relationship between perceived stress and resilience as well as the direct and indirect and total effects of spirituality and religious coping through a hypothesized mediation model in people with T2DM. Method: A cross-sectional study conducted with a total of 216 participants, out of whom 41.2% were men and 58.8% were women in the age range of 30 to 78 years (M = 56.63, SD = 11.27). The Perceived Stress Scale (PSS-14), the Spirituality Scale (SS), the Religious Coping Strategies Inventory (IEAR) and the Resilience Questionnaire were used. Results: Religious coping mediates the relationship between stress and resilience by showing a signifi...