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Objective: To compare in vitro the mechanical properties and depth of cure of bioactive bulk-fill resins versus bulk-fill composite resins. Materials and methods: An in vitro experimental study was conducted with 48 blocks of three types of resin. Each block received a load of 500 g for 30 seconds and was photopolymerized with a VALO® Cordless-Ultradent unit (1500 mW/cm2) for 4 seconds. Microhardness was evaluated using the Vickers hardness test, employing a calibrated LG® HV-1000 hardness tester. For statistical analysis, the Student's t-test and the non-parametric Kruskal-Wallis test were applied, considering statistical significance if p < 0.05. Results: The bioactive resin Beautifil® Bulk (BB) showed the highest microhardness, reaching a mean value of 55.1 VH (p < 0.01), followed by the resins Tetric® N-Ceram Bulk Fill (TNCBF) with 44.9 VH and Tetric® N-Flow Bulk Fill (TNF...