Background. Artichoke (Cynara scolymus L.) residues are a rich source of phenolic compounds, but these compounds are susceptible to external factors. Therefore, nanoencapsulation by ionic and ultrasound-assisted gelation techniques can be used as an alternative to preservation. This work aimed to determine the effects of the interaction of the following variables: chitosan (Ch) concentration, sodium tripolyphosphate (TPP), Ch/TPP ratio, pH, and sonication time to ensure high encapsulation efficiency (%EE). Materials and methods. Optimal nanoencapsulation conditions were evaluated using a 25–1 fractional factorial design to maximize nanoencapsulation efficiency (%EE) using multivariate regression analysis. Results. The model was adequate with R2 = 0.998. The optimum conditions for nanoencapsulation were Ch (0.28%), TPP (0.29%), Ch/TPP (5/1), pH (4.9) and sonication time (4.79 min). Unde...