The validation of methods is an important requirement in the practice of chemical analysis, which guarantees the quality of the drug. In this work we performed the validation of an analytical method by High Performance Liquid Chromatography (HPLC) for the dissolution test of dexamethasone 0.5 mg tablets, specificity, which determines the ability of the method to measure Dexamethasone Acetate, without interference of Parts of the excipients, results in no response of the equipment by the excipient, therefore the method is specific. Linearity; Which measures the ability of the analytical method to produce results that are proportional to the concentration of the analyte, which is demonstrated in the validation when obtaining a correlation coefficient r = 0.9999, with the minimum value being permissible of 0.9900. The accuracy of the analytical method is the degree of agreement or dispersio...