Objective: to identify the drug interactions present in the prescriptions filled by patients with Parkinson’s disease from the service of the home care program. Methodology: An observational, descriptive, retrospective cross-sectional study was designed. Results: The review of 548 filled prescriptions was carried out, 439 (80.1%) presented drug interactions, where the male sex and the age group of ≥ 80 years predominated and the most frequent comorbidities were arterial hypertension, chronic gastritis and heart failure. From the review of 439 filled prescriptions, 943 drug interactions were found. Carbidopa/Levodopa presented a higher number of drug interactions. The predominant drug interaction mechanism was pharmacodynamic (413) and according to the evaluation of the prescriptions filled through Drugs.com and classified under the Stockley Alerts criteria, 764 (81.0%) were found to ...