This research aimed to determine the relationship between frailty and quality of life in older adults during the Covid-19 pandemic in health centers in Iquitos in 2022. This was a quantitative, descriptive, correlational, and cross-sectional study, which worked with a sample of 337 older adults. Data was collected through interviews and surveys using the Edmonton Frail Scale (EFS) and the SF-12V2 questionnaire for health-related quality of life. The data was analyzed using the SPSS statistical program version 24.0. When applying the non parametric Kolmogórov-Smirnov test, a normal distribution was found in the entire sample, obtaining a p <0.00. In other words, both variables have a normal distribution. The results obtained show that 62.9% were between 60 and 74 years old, of which 37.1% were married and 18.7% were cohabiting; the educational levels with the highest percentages were pri...