Background: Self-injurious behaviors are highly prevalent in individuals with autism spectrum disorder (ASD), occurring frequently in those with associated intellectual disabilities as well as in those without intellectual impairment. Single-case studies have found that functional communication training helps regulate self-injurious behaviors and repetitive behaviors, particularly in children with ASD. However, no review identifies whether there is experimental evidence to support the use of this treatment. Objective: Our review aims to determine the efficacy of functional communication training for regulating self-injurious behavior in children and adolescents diagnosed with ASD. Methods: A systematic review was conducted.PubMed, Scopus, Web of Science, and Embase were searched for single-case experimental studies and randomized clinical trials. Result...