Cocoa (Theobroma cacao L.) is one of the main crops in Latin American and African countries, its almonds being marketed to produce chocolate. However, different biotic factors can negatively affect the crop production, especially on small farms where management by farmers is scarce or nonexistent. Lethal wilt (Ceratocystis cacaofunesta Engelbrecht & Harrington) together with beetle borers (Coleoptera: Curculionidae: Scolytinae), continue to be the main problems affecting cocoa. It has been observed that both organisms interact intrinsically inside the trunks of cacao trees. Despite the importance of this interaction, in general, the countless research and review articles carried out to date have focused mainly on studying each biotic factor separately or have been addressed in a general way. Thus, in this review we mainly focus on the interaction between the Lethal wilt and the borer...