Obesity is a metabolic condition with a continuous increasing rate, being considered today a “pandemic”. Due to this and the vast number of diseases it is associated with, there is a need for a treatment of this condition that is both effective and healthy in a comprehensive way. In this context, the concepts of lifestyle medicine and plant-based diets have emerged in medicine and in scientific research, and the latter have demonstrated benefits in all these areas and are being part of several scientific association’s recommendations today. In this article, a plant-based diet is briefly defined, and the mechanisms by which this type of diet provides benefits for the control of body weight are explored, including the satiety it generates and its characteristic low caloric density, the higher thermic effect of foods, the positive modulation of the gut microbiota, its effects on the i...