Spondias mombin L., is a plant dispersed throughout the tropical regions of South America, Africa and Asia, where the leaves and bark are used in preparations for neuropsychiatric disorders due to their metabolite content. The present study was designed to describe the optimal experimental conditions, using the response surface methodology to maximize the extraction efficiency of bark and leaves of Spondias mombin L., based on an experimental design to validate an appropriate method to simultaneously quantify the yield. extraction and total phenol compounds. The main variables were evaluated, which were the extraction time and solvent ratio, the extraction of the bark and leaves through the composition that shows 66.46±0.86% humidity in the bark and 70.55±0.08% humidity in the leaves, resulting in significant difference (p<0.05) and 3.87±0.09% of ash in the bark and 3.20±0.67 in resp...