The resistence to the antibiotics constitutes one of the most important problems of the public health in the whole world._x000D_ The enterobacterias producer of the carbapenemases represents the greatest threat. The carbapenemasas are potent ensymes that inactive the carbapenem antibiotics and in general to all the betalactam antibiotics._x000D_ This research aimed to determine the frecuency of blaKPC and blaOXA-48 in 66 growth bacterial cultures of Escherichia coli and 34 growth bacterial cultures of Klebsiella pneumonia provided by the Belen Hospital of Trujillo during the months of January to March of 2018. For this, it was determined betalactamases ensymes type of extended-spectrum BLEE and by identifying the carbapenemases ensyme type through the Hodge Test modified the total of population under the standards of the CLSI 2015.The synergy of disk tet with APB was realized to the posi...