The results of a cytogenetic study carried out in two female Miniature Pinscher who died after birth, one affected with meningoencephalocele (MEC) and the other apparently normal, are presented. The analysis of 156 metaphases (75 of the specimen with pathology and 81 without pathology) showed a typical unimodal female complement 2n = 78 (76, XX) in 95.06% of all metaphases in the normal puppy, while the puppy with ECM showed a multimodal karyotype with three chromosomally distinct cell lines: 2n = 78 (36%); 77 (28%); 76 (10.67%). The remaining 25.33% of cells corresponded to cells with less than 76 chromosomes. Statistical analysis of the medians of the chromosome counts using the Man-Whitney U test between the normal (median = 78; median range = 51.81) and affected (median = 77; median range = 26.69) puppies revealed hig...

            The results of a cytogenetic study carried out in two female Miniature Pinscher who died after birth, one affected with meningoencephalocele (MEC) and the other apparently normal, are presented. The analysis of 156 metaphases (75 of the specimen with pathology and 81 without pathology) showed a typical unimodal female complement 2n = 78 (76, XX) in 95.06% of all metaphases in the normal puppy, while the puppy with ECM showed a multimodal karyotype with three chromosomally distinct cell lines: 2n = 78 (36%); 77 (28%); 76 (10.67%). The remaining 25.33% of cells corresponded to cells with less than 76 chromosomes. Statistical analysis of the medians of the chromosome counts using the Man-Whitney U test between the normal (median = 78; median range = 51.81) and affected (median = 77; median range = 26.69) puppies revealed hig...