This research explores the effect of psychological capital on self-leadership, and the mediation of mindfulness in this relationship. To such aim, structural equation modeling is used to validate the research hypothesis in a sample of 100 participants from companies from a variety of economic sectors. The results confirmed that the psychological capital maintains a positive and meaningful relationship with self- leadership and mindfulness, respectively. In addition, mindfulness maintains a positive and meaningful correlation with self-leadership. Finally, the research evidenced the complementary mediation of mindfulness in the relationship between psychological capital and self-leadership. These findings reveal aspects that contribute to the improvement of employees’ performance by validating the relationship among these three constructs in an empirical and integral fashion, even when ...