Fibromyalgia is a syndrome that causes generalized and diffuse muscle pain accompanied by fatigue, although other symptoms also appear, such as depression, anxiety, sleep and rest disturbances, allodynia, and cognitive, psychological and social problems. These symptoms notably affect the patients' quality of life. The forms of presentation of the pathology increase the difficulty of diagnosis and treatment for professionals who treat these patients, with a significant prevalence ratio of 21:1 in favor of women over men. On the other hand, this disease entails a high economic cost, as 2/3 of the expenses are not directly invested to treat the pathology; therefore, they are considered losses. The objective of this review is to demonstrate the effectiveness of adding various active treatments, compared to the usual pharmacological treatment, in improving quality of life and reducing pain an...