Cytomegalovirus (CMV) is the leading cause of congenital infection in developed countries, affecting 0.3 to 0.6% of all live births in Europe. Primary CMV infection occurs in 1 to 4% of seronegative women during pregnancy and may be transmitted to the fetus in 40% of cases. Up to 10% of intrauterine CMV infections result in symptomatic congenital disease at birth. Half of these children and 13% of those born with asymptomatic infection will develop long-term sequelae, especially neurosensory hearing loss and mental retardation. Accurate diagnosis of primary maternal and fetal infection is now possible using the avidity index of anti-CMV IgG and virological testing to detect the virus in amniotic fluid. The gold standard for diagnosis of congenital CMV infection is the detection of the virus in urine within the first 2 weeks of life by rapid cell culture techniques (shell vial) or nucleic...

La micosis fungoide es una neoplasia maligna originada en los linfocitos T. Usualmente inicia con la aparición de manchas planas o estadio de mancha. Con el correr de los años, las lesiones van siendo infiltrantes, apareciendo las placas o estadio de placas. Presentamos a un paciente de sexo femenino de 50 años con hallazgos clínicos e histopatológicos de micosis fungoide en estadio eritematoso o manchas a nivel de vulva.

Heterotopic pregnancy is the simultaneous development of an intrauterine and an ectopic pregnancy. This complication is increasing due to infertility treatment, especially assisted reproduction techniques. There are two types: induced (associated with in vitro fertilization techniques, rate 1:1 000 to 1: 1 500 pregnancies) or spontaneous (1:20 000 to 1:80 000 pregnancies). Causal factors for spontaneous heterotopic pregnancies include pelvic inflammatory disease, use of intrauterine device or hormonal devices, previous pelvic surgery, and history of ectopic pregnancy. We present two cases of spontaneous heterotopic pregnancies.

Cornual pregnancy is a rare entity associated with high morbidity and mortality. Diagnosis is challenging because the embryo usually appears on ultrasound as localized inside the uterus. Cornual pregnancy is more dangerous than other ectopic pregnancies, and cornual rupture may lead to severe maternal hemorrhage. It has the same risk factors as tubal pregnancy. Early diagnosis allows either medical treatment with methotrexate or conservative surgical treatments. We present a case of cornual pregnancy with unusual evolution to a single dose of methotrexate.