La presente investigación tiene como objetivo identificar y evaluar compuestos naturales peruanos con capacidad inhibitoria in silico de las glutatión transferasas bacterianas (GST), enzimas clave en la resistencia antimicrobiana. Mediante simulaciones computacionales y cribado virtual, se analizaron 300 compuestos provenientes de especies nativas como Lepidium meyenii (maca), Curcuma longa (cúrcuma), y Mauritia flexuosa (aguaje). Los resultados revelaron que metabolitos como la curcumina y alcaloides derivados de la maca mostraron alta afinidad hacia las GST de Escherichia coli y Pseudomonas aeruginosa, con valores de energía de unión significativamente negativos. Estos hallazgos subrayan el potencial de los recursos naturales peruanos en el diseño de estrategias innovadoras para combatir la resistencia antimicrobiana. Sin embargo, se destaca la necesidad de validaciones in vitro ...

“Introduction: Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally, becoming a long-lasting pandemic. Dengue is the most common arboviral disease in tropical and subtropical regions worldwide. COVID-19 and dengue coinfections have been reported, associated with worse outcomes with significant morbidity and mortality. Therefore, this study aims to determine the epidemiological situation of COVID-19 and dengue coinfection in Latin America. Methods: A systematic literature review was performed using PubMed, Scopus, Embase, Web of Science, LILACS, and BVS databases from January 1, 2020, to September 4, 2021. The key search terms used were ““dengue““ and ““COVID-19““. Results: Nineteen published articles were included. The studies were case reports with a detailed description of the coinfection’s cl...