Introduction: The consumption of narcotic substances constitutes a serious social problem that affects the quality of life of those who consume it in a customary way. Knowledge of the agents that increase the probability of consumption is necessary to establish prevention criteria in higher education. Objective: Analyze the drug use of university students in relation to their socio-demographic variables and leisure activities. The study carried out had a quantitative approach with a non-experimental, cross-sectional, descriptive and correlational design. Method: A sample of 1755 students (752 women and 1003 men) were applied the ISTS Socioeconomic Survey and the EST-Diagnosis survey of the situation of consumption of alcohol, tobacco and other psychoactive substances in the university community of the Central University of the Ecuador, confirming the inference through the Chi square stat...