It was determined the levels of antioxidant enzymes: Glutathione Peroxidase (GPx), Superoxide Dismutase (SOD) and Catalase (CAT), and the concentratíon of Malondialdehyde (MDA) as an indicator of lipid peroxidatíon in erythrocytes of 60 apparently healthy people: 30 residents at high altitude (Cerro de Paseo, 4340 m) and 30 residents at sea level (Lima, 150 m). We found erythrocyte GPx levels higher in high altitude natives than in the sea level ones (p < .001). No statistically significant differencc was found between the val u es obtained for SOD in high altitude na ti ves and those of sea leveL The CAT activity was lower in subjccts of high altitude in relation to those of sea level (p < .001). High altitude native MDA levels also were lower than those obtained at sea level (p < .001). We concluded that Glutathione Peroxidase is the main antioxidant enzyme for the detoxific...

Se determinó los niveles de las enzimas antioxidantes: glutation peroxidasa (GPx), su peróxido dismutasa (SOD) y catalasa(CAT); y la concentración de malondialdehído (MDA) como un indicador de la peroxidación lipídica, en eritrocitos de 60 personas aparentemente sanas: 30 residentes de la altura (Cerro de Paseo, 4340 m) y 30 residentes de nivel del mar (Lima,150m). Se encontró niveles eritrocitarios de GPx mayores en los nativos de altura que en los de nivel del mar (p < 0,001). No se encontró diferencia estadísticamente significativa entre los valores obtenidos para la SOD en los nativos de altura y en los de nivel del mar. La actividad de la CAT fue menor en los sujetos de altura en relación con los de nivel del mar(p < 0,001). Los niveles de MDA en los nativos de altura también fueron menores que los obtenidos a nivel del mar (p < 0,001). Se concluye que la glutati...

In order to analyze the activity of the serum enzyme paraoxonase, phenotype distribution and its relationship with lipid profile and oxidative stress, in an elderly population from Cerro de Pasco city(4330 m), were studied blood serum of 30 men aged 60 years and 40 postmenopausal women. Paraoxon were used as substrate for measuring the activity of paraoxonase basal and stimulated with NaCl 1 M and measuring phenylacetate arylesterase activity. The lipid profile was measured using commercial kits, apolipoproteins A-1 and B by turbidimetric methods and malondialdehyde with thiobarbituric acid. The mean values of lipid profile, APO B, and malondialdehyde (expressed as TBARS) between men and women do not differ significantly. APO A-1 is significantly higher in women than in men. The activities of the PON 1 basal and stimulated not differ significantly between the two groups. There was signif...

In order to analyze the activity of the serum enzyme paraoxonase, phenotype distribution and its relationship with lipid profile and oxidative stress, in an elderly population from Cerro de Pasco city(4330 m), were studied blood serum of 30 men aged 60 years and 40 postmenopausal women. Paraoxon were used as substrate for measuring the activity of paraoxonase basal and stimulated with NaCl 1 M and measuring phenylacetate arylesterase activity. The lipid profile was measured using commercial kits, apolipoproteins A-1 and B by turbidimetric methods and malondialdehyde with thiobarbituric acid. The mean values of lipid profile, APO B, and malondialdehyde (expressed as TBARS) between men and women do not differ significantly. APO A-1 is significantly higher in women than in men. The activities of the PON 1 basal and stimulated not differ significantly between the two groups. There was signif...