Antibiotic resistance represents a challenge in the management of infections in critically ill patients with COVID-19, and may influence the clinical evolution and survival of patients in the Intensive Care Unit of Hospital III EsSalud Iquitos 2021. The objective of the study was to determine the relationship between antibiotic resistance and survival in patients diagnosed with COVID-19 in the Intensive Care Unit of Hospital III EsSalud Iquitos 2021. The observational, analytical, and retrospective quantitative methodology. The results obtained are: 68% were male; average age 56 years; 78% had at least one comorbidity (obesity 54%); 71% of patients reported self-medication with antibiotics and 91% with corticosteroids before admission. 45% had infections by multidrug resistant microorganisms, predominantly Klebsiella pneumoniae and Acinetobacter baumannii. A significant association was f...