Tuberculosis is a leading killing disease worldwide with more than 9 million people a ected per year. Current diagnostic methods exhibit several disadvantages; one of the most promising alternatives to overcome this is the development of nanostructured diagnostic systems which are able to detect molecules associated with certain diseases. Graphene since its discovery has been the focus for the development of these sensing elements due to its excellent electronic properties. In this work, a graphene-based eld e ect transistor (FET) has been developed for tuberculosis DNA detection, in order to set the basis for a diagnostic method that overcomes current limitations. The sensing elements composed of graphene monolayers were manufactured in the stages of annealing of the substrate, addition of the linker and functionalization with the addition of a probe DNA for tuberculosis detection. Addi...

En el presente trabajo de investigación se ha empleado la técnica de procesamiento por fricción batido (Friction Stir Processing: FSP) para generar superficies que combinen las buenas propiedades de biocompatibilidad del titanio y la hidroxiapatita. Se utilizó un sustrato de titanio CP grado 2, incorporándose en la zona de batido dos tipos de nanopartículas de hidroxiapatita a diferentes porcentajes en peso: hidroxiapatita pura e hidroxiapatita dopada con óxido de silicio. Se realizaron dos pases con la herramienta de procesamiento, los parámetros para el primer y segundo pase fueron: velocidad de rotación de 800 y 1100 rpm y velocidad de avance de 1200 y 1100 mm/min respectivamente. Los materiales empleados y los nanocompuestos resultantes fueron caracterizados mediante microscopía óptica, microscopía electrónica de barrido y espectroscopía de energía dispersiva. Los resu...

Tuberculosis is a leading killing disease worldwide with more than 9 million people a ected per year. Current diagnostic methods exhibit several disadvantages; one of the most promising alternatives to overcome this is the development of nanostructured diagnostic systems which are able to detect molecules associated with certain diseases. Graphene since its discovery has been the focus for the development of these sensing elements due to its excellent electronic properties. In this work, a graphene-based eld e ect transistor (FET) has been developed for tuberculosis DNA detection, in order to set the basis for a diagnostic method that overcomes current limitations. The sensing elements composed of graphene monolayers were manufactured in the stages of annealing of the substrate, addition of the linker and functionalization with the addition of a probe DNA for tuberculosis detection. Addi...

En el presente trabajo de investigación se ha empleado la técnica de procesamiento por fricción batido (Friction Stir Processing: FSP) para generar superficies que combinen las buenas propiedades de biocompatibilidad del titanio y la hidroxiapatita. Se utilizó un sustrato de titanio CP grado 2, incorporándose en la zona de batido dos tipos de nanopartículas de hidroxiapatita a diferentes porcentajes en peso: hidroxiapatita pura e hidroxiapatita dopada con óxido de silicio. Se realizaron dos pases con la herramienta de procesamiento, los parámetros para el primer y segundo pase fueron: velocidad de rotación de 800 y 1100 rpm y velocidad de avance de 1200 y 1100 mm/min respectivamente. Los materiales empleados y los nanocompuestos resultantes fueron caracterizados mediante microscopía óptica, microscopía electrónica de barrido y espectroscopía de energía dispersiva. Los resu...