This article was developed thanks to the funding of Cienciactiva, an initiative of the National Council of Science, Technology and Technological Innovation (CONCYTEC). Contract No. 227-2015-FONDECYT. Thanks to the authorities and staff of PNP Huaraz Polyclinic for the support provided to the SERUMS staff to carry out this study (May 2012-May 2013). Thanks to the personnel of the company Innovation and Development for the support in the design of the study and the logistics and, to Rogelio Martínez Diez of the University of Valladolid-Spain for collaborating in the writing of the manuscript.

Endophytic and epiphytic bacteria and fungi that live in association with macroalgae produce compounds that favor the growth of the host, being in some cases more efficient than those produced by the terrestrial microbiome. This review collects information from articles published in Scopus, ScienceDirect, PubMed, and Wiley Online Library. Articles were organized according to their antimicrobial properties, synthesis of hydrolytic enzymes, production of other bioactive compounds by bacteria and fungi, and their application. The information collected showed that bacteria and fungi associated with macroalgae have the ability to inhibit bacteria, fungi, yeasts, and protozoa that affect aquaculture, public health, and the food industry, reporting that the pyrenocines A, B, E, and S isolated from Phaeosphaeria sp. Inhibited pathogenic protozoa. Additionally, other compounds identified as alkal...