The genus Passiflora accounts for 17% of global flavonoid production, and several strategies have been explored to increase their production in these plants, given the growing demand for these metabolites. The aim of this study is to examine the published literature on the correlation between flavonoid concentrations in Passiflora genus leaves and factors such as microorganism presence, soil fertility, fertilizer use, soil conditioners, agronomic practices, weather patterns, and plant phenology. The search was conducted across nine databases. Web of Science, Nature, Agris, Dialnet, Scielo, Science Database-ProQuest, Scopus (Elsevier), Springer, and EBSCOhost and two search engines: Google Scholar and Semantic Scholar, obtaining 19 indexed articles. The results indicate that treatments incorporating a single biotic or abiotic factor in the crop lead to a 380% increase in the production of...