The effect of energy and protein densities of diets on homeostasis, metabolic profile and productive performance during pre and postpartum periods of Romosinuano cows was evaluated. Thirty grazing cows were assigned to three nutritional supplementation groups: TC: 0.0, T1: 2.35 and T2: 2.8 kg/animal/day of energy-protein supplement. The experiment ran from 30 days before calving to 60 days postpartum. Body weight (BW), body condition (BCS) and serum concentrations of glucose, cholesterol, total protein, β-hydroxybutyrate, non-esterified fatty acids (NEFAs), urea, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were evaluated. The prepartum supplementation did not affect BW (p=0.4557) nor BCS (p=0.1893). In the postpartum period, there was a significant effect of supplementation on BW (p=0.0343) and BCS (p=0.029) in T1 and T2 and on glucose at prepartum in T2 (p=0.001...