High blood pressure is a common and silent chronic disease that increases the risk of cardiovascular, renal, and cerebral complications. It affects millions of people worldwide, many without diagnosis or adequate treatment. Its control represents a major public health challenge, especially in developing countries.  Objective: To analyze the literature associated with the use of antihypertensives such as sacubitril/valsartan and their effectiveness, highlighting their importance in public health. Material and Methods: The PRISMA methodology was applied, initially identifying 326 articles, of which 298 were excluded from the analysis because they were review articles and not case reports. Next, 15 open-access full-text articles were selected, 9 of which were directly related to our research objective. In this article, we included only original clinical trials published between 2021 an...