Objective: This study aimed to compare the effectiveness of the Tagger technique and the lateral condensation technique with different obturation cements in achieving optimal apical sealing in endodontic treatments. Methods: An in vitro study was conducted on 68 extracted human upper or lower first premolars. Teeth were randomly divided into four experimental groups (n=17) based on two obturation techniques and endodontic sealers employed, as follows: Group 1, Tagger technique with the zinc oxide-eugenol sealer; Group 2, Tagger technique with the resin-based sealer; Group 3, lateral condensation technique with zinc oxide-eugenol sealer, and Group 4, lateral condensation technique with resin-based sealer. Homogeneity of the gutta-percha mass and apical obliteration were evaluated under a digital stereomicroscope. Data were analyzed using the chi-square test, and a P-value<0.05 was conside...