The present study is aimed at determining the rating of the cold chain during the process of packaging, transport and distribution of a pharmaceutical distributor. The investigation begins with selection of the simulation product. Then, the equipment to be used was tested and the Gel packs at -10 ° C were adjusted. Subsequently, two packaging classes A and B were designed for the container of thermal insulation type 1 (42cm x 32cm x 26cm), also C and D for type 2 (24cm x 29cm x 24.5cm). Finally, the qualification tests of the packing, transport and distribution process are carried out, where the temperature is monitored from the point of origin to the point of final destination. It is concluded that the process of packaging, transport and distribution complies with keeping the cold chain within the established range

The present research work was aimed at determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the hydroethanolic extract of the Persea americana "avocado" seeds against Staphylococcus epidermidis; from the populated center of the district of Moche, province of Trujillo. The hydroetanolic extract of Persea americana seeds was obtained by mashing with constant agitation for 15 days. It also presented the following organoleptic characteristics: dark orange color, suigéneris smell, liquid texture, bitter taste. Then the CMI was determined by the M27-A3 method standardized by the Clinical and Laboratory Standards Institute (CLSI), adapted to the research, ten concentrations were used; and the CMB was performed by the method of agar dilution using the technique of surface planting in Muller-Hinton agar, a value of 12.5% was obtained, for bot...