Objective: To analyze the operational management of the infection control plan (ICP) for tuberculosis in hospital care settings in a city with a high burden of the disease. Methods. An analysis of operational management was conducted in 37 institutions providing health services in the city of Cali, by applying a tool to collect information on the implementation of administrative, environmental and respiratory protection control measures. Additionally, the program design evaluation was conducted. Results: Administrative control measures were not implemented in 65 % of the institutions, primarily due to the absence of written infection control plans and a lack of risk assessment. 70 % of institutions failed to comply with environmental measures, especially in the verification of air flows, while respiratory control was well implemented in 78. However, the absence of ft testing for N95 resp...