The plasminogen activator system is actively involved in periodontal disease dynamics and is finely balanced in terms of their activators and inhibitors, although there are periods where exacerbation of periodontal pockets can break the delicate balance between activators (t-PA) and inhibitors of plasminogen (PAI-2) triggering the progression of periodontal disease include the participation of bacterial pathogens Porphyromonas gingivalis as characterized by generating the major imbalance between activators and inhibitors with a consequent increase in fibrinolytic activity. The effects of the imbalance of the constituents of plasminogen activator system in particular t-PA takes on more importance in the gingival level bleeding events in patients with deficiencies of coagulation factors such as warfarin anticoagulation or severe liver disease such as cirrhosis.The plasminogen activator sys...

This study analysed the hemostatic clinical effect of the tranexamic acid mouthwash against the conventional treatment in patients treated with oral anticoagulants. After suspending the anticoagulant medication for three days, ten surgical procedures were carried out in ten patients(control group), and without modifying or altering the . anticoagulant treatment, 20 procedures were carried out using tranexamic acid in 15 palients(case group). In this last group, before suturing the surgical fleld was irrigated with tranexamic acid solution at 5%. After that, patients of case group were instructed to use 10 ml of the mouthwash for two minutes, tour times a day per seven days. The only statisticaly sígnificative difference (p 0,05) between both groups at the beginning of this research, IOas the level of the anlicoagulation. The average of the INR for case and control group was 2,53 and 1,1...

The plasminogen activator system is actively involved in periodontal disease dynamics and is finely balanced in terms of their activators and inhibitors, although there are periods where exacerbation of periodontal pockets can break the delicate balance between activators (t-PA) and inhibitors of plasminogen (PAI-2) triggering the progression of periodontal disease include the participation of bacterial pathogens Porphyromonas gingivalis as characterized by generating the major imbalance between activators and inhibitors with a consequent increase in fibrinolytic activity. The effects of the imbalance of the constituents of plasminogen activator system in particular t-PA takes on more importance in the gingival level bleeding events in patients with deficiencies of coagulation factors such as warfarin anticoagulation or severe liver disease such as cirrhosis.The plasminogen activator sys...

This study analysed the hemostatic clinical effect of the tranexamic acid mouthwash against the conventional treatment in patients treated with oral anticoagulants. After suspending the anticoagulant medication for three days, ten surgical procedures were carried out in ten patients(control group), and without modifying or altering the . anticoagulant treatment, 20 procedures were carried out using tranexamic acid in 15 palients(case group). In this last group, before suturing the surgical fleld was irrigated with tranexamic acid solution at 5%. After that, patients of case group were instructed to use 10 ml of the mouthwash for two minutes, tour times a day per seven days. The only statisticaly sígnificative difference (p 0,05) between both groups at the beginning of this research, IOas the level of the anlicoagulation. The average of the INR for case and control group was 2,53 and 1,1...