Study Objectives Assess acute changes in nocturnal sleep oxygenation, sleep disordered breathing and symptoms of Acute Mountain Sickness (AMS) in healthy High Altitude (HA) sojourners. Methods Ten subjects born at Sea Level (SL) were enrolled and underwent nocturnal polygraphy for 5 consecutive nights at HA and 2 nights before and after HA (2761 m). Nocturnal oxygen profiles were characterized by the mean Oxyhaemoglobin Saturation (SpO2) during sleep, and sleep apnea severity was represented by the Apnea-Hypopnea Index (AHI). Repeated measures linear regression was used to examine responses in outcome variables (SpO2, logAHI and LLS) between HA and SL. Mean SpO2 on night 1 at HA was used to stratify post-hoc analyses based on mean level of nocturnal desaturation and logAHI. Subjects completed the Lake-Louise Score (LLS) survey every day. Results Compared to SL, mean SpO2 was lower at HA ...

Extreme environments Morrope and Bayovar Salt lagoons, several ecosystems and microhabitats remain unexplored, and little is known about the diversity of Actinobacteria. We suggest that the endemic bacteria present in this extreme environment is a source of active molecules with anticancer, antimicrobial, and antiparasitic properties. Using phenotypic and genotypic characterization techniques, including 16S rRNA sequencing, we identified these bacteria as members of the genera Streptomyces, Pseudonocardia, Staphylococcus, Bacillus, and Pseudomonas. Actinobacteria strains were found predominantly. Phylogenetic analysis revealed 13 Actinobacteria clusters of Streptomyces, the main genus. Three Streptomycetes, strains MW562814, MW562805, and MW562807 showed antiproliferative activities against three tumor cell lines: U251 glioma, MCF7 breast, and NCI-H460 lung (non-small cell type); and ant...