1
artículo
Publicado 2011
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Persistent jet structures along zonal and meridional fields, believed to be caused by stationary gravity waves, were detected in February 1999 in MST wind measurements of the troposphere and lower stratosphere over Jicamarca, Peru. Over a seven day span, two days of observations showed signatures of a Doppler ducted gravity wave in the upper troposphere/lower stratosphere. Herein we present the observations, their characteristics, and results of numerical simulations used to mimic these observed features. Though a fair replication of the observed ducted structure in the numerical model is found, the observed period of ~90 min is nonetheless longer than anticipated and raises concern as to the specific physical nature of the observed structures. However, given the high quality of the observations, we demonstrate that continued analysis of this data set and concurrent modeling will allow f...
2
artículo
Publicado 2021
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Background: First-line therapy for advanced oesophageal cancer is currently limited to fluoropyrimidine plus platinum-based chemotherapy. We aimed to evaluate the antitumour activity of pembrolizumab plus chemotherapy versus chemotherapy alone as first-line treatment in advanced oesophageal cancer and Siewert type 1 gastro-oesophageal junction cancer. Methods: We did a randomised, placebo-controlled, double-blind, phase 3 study across 168 medical centres in 26 countries. Patients aged 18 years or older with previously untreated, histologically or cytologically confirmed, locally advanced, unresectable or metastatic oesophageal cancer or Siewert type 1 gastro-oesophageal junction cancer (regardless of PD-L1 status), measurable disease per Response Evaluation Criteria in Solid Tumors version 1.1, and Eastern Cooperative Oncology Group performance status of 0-1, were randomly assigned (1:1)...
