Evaluar si existe asociación entre el sobrepeso pregestacional y la anemia durante el primer trimestre, en gestantes de localidades de altura. Materiales y Métodos: Estudio transversal - correlacional. Se incluyó a 222 gestantes de localidades de altura, con edad gestacional menor o igual a 12 semanas y que fueron atendidas en establecimientos de salud pertenecientes a la Red de Salud Conchucos Norte-Pomabamba, durante el 2022. Estas gestantes tenían sobrepeso o peso normal pregestacional y fueron clasificadas por su condición de tener anemia o no tenerla. La información fue recolectada a partir del Sistema de Vigilancia del Estado Nutricional (SIEN). Para el análisis estadístico se empleó las pruebas de Chi-cuadrado, T de Student, U de Mann-Whitney y modelos de regresión logística ajustados. Resultados: El 9.9% de las gestantes evaluadas reportó niveles de hemoglobina correg...

Autosomal Dominant Polycystic Kidney Disease, known by its acronym ADPKD (Autosomal Dominant Polycystic kidney disease), is a condition of genetic origin characterized by two types of mutations in the PKD1 and PKD2 genes that code for polycystins (PC) 1 and 2, respectively. It is associated with extrarenal manifestations, both cystic and non-cystic; the liver is the most affected organ within the cystic manifestations; as well as cerebral vascular alterations, in non-cystic ones. We report a 44-year-old woman with polycystic hepato-renal disease (PLKD) complicated by intestinal subocclusion.

COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the infection of its target cells; also to propose molecules from in silico studies that inhibit proteins of the viral cycle for potential pharmacological treatments. The SARS-CoV-2 genome has ORFs that encode sixteen non-structural proteins (Nsp1-16), four structural proteins (Spike, Envelope, Membrane, and Nucleocapsid), and nine accessory proteins; that fulfill various functions in the entry of the virus and its viral cycle. In silico studies of drugs such as disulfiram and viomycin, and molecules found in plants as Azadirachta indica, the tea plant, and Andrographis paniculata have shown inhibitory effects on the SARS-CoV-2 viral cycle.

COVID-19 is a disease caused by SARS-CoV-2, a virus that represents a serious threat to global health. The objective of the article is to deepen into the structure of the structural and non-structural proteins of SARS-CoV-2 and their role during the infection of its target cells; also to propose molecules from in silico studies that inhibit proteins of the viral cycle for potential pharmacological treatments. The SARS-CoV-2 genome has ORFs that encode sixteen non-structural proteins (Nsp1-16), four structural proteins (Spike, Envelope, Membrane, and Nucleocapsid), and nine accessory proteins; that fulfill various functions in the entry of the virus and its viral cycle. In silico studies of drugs such as disulfiram and viomycin, and molecules found in plants as Azadirachta indica, the tea plant, and Andrographis paniculata have shown inhibitory effects on the SARS-CoV-2 viral cycle.