Background: Prematurity is a serious public health problem, due to its high morbidity and mortality, with 15 million premature births and one million deaths annually worldwide. The main causes of neonatal mortality in premature infants are necrotizing enterocolitis and late sepsis. In Peru, the percentage of premature births increased from 6.4% in 2020 to 7.5% in 2023, with an average of 30,000 premature newborns annually. In 2023, 70% of neonatal deaths corresponded to premature babies. The National Maternal Perinatal Institute reported high rates of neonatal mortality, especially in premature babies weighing less than 1500 grams. It is worth mentioning that of all neonatal deaths by 2023, 70% corresponded to premature babies and 46.5% to those less than 1500g. Objective: Determine the protective effect of colostrotherapy in premature newborns with birth weight less than 1500g in the IN...