Objective: To determine whether epidemiological changes occurred among patients hospitalized in an internal medicine unit at Hospital Nacional Edgardo Rebagliati Martins by comparing data from 2008 and 2018. Materials and methods: An observational, retrospective and cross-sectional study was conducted using an analytical-descriptive approach and a non-experimental design. The study utilized nursing records from 1,640 patients over 18 years of age who were hospitalized in Internal Medicine Unit No. 5 (floor 7C) at Hospital Nacional Edgardo Rebagliati Martins (Jesús María, Lima, Peru) during 2008 and 2018. Sociodemographic variables (sex and age) and clinical variables (unit of origin, type of disease, hospital stay and discharge condition) were analyzed. Data entry and database creation were carried out using Microsoft Excel, while data processing was performed with Microsoft R Open 4.0...