This study is a geochemical investigation of the Andean and Foreland basins of the Amazon River at high spatial and time resolution, carried out within the framework of the HYBAM research program (Hydro-geodynamics of the Amazon Basin). Monthly sampling was carried out at 27 gauging stations located in the upper tributaries of the Amazon Basin (from north to south: the Napo, Marañon, Ucayali, Madre de Dios-Beni and Mamore Rivers). The aim of this paper is to estimate the present-day chemical weathering rate (CWR), as well as the flux of CO2 consumption from total and silicate weathering in the Andes and Foreland Amazon basins, and to discuss their distribution as a function of geomorphic and structural parameters. Based on the forward method, the Napo and other Ecuadorian basins present high silicate weathering rates in comparison with the other basins. We confirm that the Marañon and ...