Introduction: Lead toxicity has been linked to different diseases in humans and several evidences suggest a strong relationship with the observed damage on reproductive function in humans and rodents. Method: Mice were given a single dose of lead nitrate (NP) (50mg/kg/bw), which were euthanized seven days post-injection with the aim of evaluating sperm to come out from the seminiferous tubules and are in transit through the epididymis. Also, the TUNEL test was done to evaluate the sperm DNA fragmentation.  Results: The decrease in body weight in mice treated with LN (p <0.05), suggest a toxic systemic effect. However, the same did’n happen on the reproductive system because the weights of the testes, epididymis, prostate and seminal vesicles were not altered (p>0.05), in the same way physiological values such as sperm concentration and motility didn´t decrease with the treatmen...