This report aims to present documentary evidence that the results produced are reliable, consistent and reproducible in the conditions. Was proposed analytical method validation by High Performance Liquid Chromatography of Dexamethasone and Loratadine Tablets Coated, evaluating parameters such as specificity or selectivity, linearity, precision, accuracy and stability in order to comply with the requirements of U.S. Pharmacopeia (USP), International Conference on Harmonization Tripartite (ICH) and recommendations of the Spanish Association of Pharmaceutical Industry (AEFI). Once the defined working conditions, the respective analysis for evaluating the validation parameters were performed. It was demonstrated by the experimental design, analytical methodology that meets the characteristic that is linear, because it was obtained r = 0.999376; r2 = 0.998752 for Dexamethasone r = 0.999591; ...