Introduction. Studies on the infection of Helicobacter pylori and the IL-1B gene play an important role within inflammation and its proinflammatory properties that promote defense against pathogens. Polymorphisms have been related to a higher production of IL-1β associated with hypochlorhydria and cancer development under H. pylori infection, so the objective of this study was to evaluate polymorphism in the +3954 region (IL- 1B C> T) of the interleukin IL1β gene. Method. the blood samples were donated and collected to be processed for the determination of H. pylori, by means of the Urease Test (Proindusquim), in the city of Villahermosa Tabasco, Mexico, separating positive and negative samples (control), the positive samples were analyzed by PCR and enzymatic digestion for polymorphic analysis in the +3954 region (IL-1B C> T). Results. 245 samples 78 cases of H. p...

Introduction. Studies on the infection of Helicobacter pylori and the IL-1B gene play an important role within inflammation and its proinflammatory properties that promote defense against pathogens. Polymorphisms have been related to a higher production of IL-1β associated with hypochlorhydria and cancer development under H. pylori infection, so the objective of this study was to evaluate polymorphism in the +3954 region (IL- 1B C> T) of the interleukin IL1β gene. Method. the blood samples were donated and collected to be processed for the determination of H. pylori, by means of the Urease Test (Proindusquim), in the city of Villahermosa Tabasco, Mexico, separating positive and negative samples (control), the positive samples were analyzed by PCR and enzymatic digestion for polymorphic analysis in the +3954 region (IL-1B C> T). Results. 245 samples 78 cases of H. p...