Evalúa la actividad antioxidante y antifúngica sobre Candida albicans ATCC 10231 y la composición química del aceite esencial de las hojas de Rosmarinus officinalis L. “romero“ mediante cromatografía de gases/espectrometría de masas (CG/EM). Se utiliza un sistema de hidrodestilación con arrastre de vapor de agua para obtener el aceite esencial, que tuvo un rendimiento de 1,1% v/p. Los componentes químicos se descubrieron mediante el análisis cualitativo de CG/EM. Se utilizan dos métodos para evaluar la actividad antioxidante del aceite in vitro: captación del radical 2,2- difenil-1-picrilhidrazil (DPPH) y captación del radical ácido 2,2-azinobis (3- etilbenzodiazolin)-6-sulfonico (ABTS•+). La actividad antifúngica se demuestra mediante la determinación de la CMI y la microdilución colorimétrica en microplacas. El análisis CG/EM proporciona una explicación de 53 c...

Introduction: Candida albicans may cause severe invasive infections and frequently superficial lesions. Drugs used in treatment present drawbacks and search of alternatives becomes necessary. Objectives: To determine the activity of Thymus vulgaris essential oil (EO) alone and combined with EDTA on Candida albicans, and formulate a cream with EO supplemented with natural terpenes. Design:In vitro experimental and in vivo toxicity study. Setting: Faculty of Medicine and Faculty of Pharmacy, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material:Candida albicans strain for in vitro study and rabbits for dermal toxicity tests. Methods:Antifungal activity was determined by agar well diffusion method, and minimum inhibitory concentration (MIC) by broth microdilution method. A cream was formulated with EO 1% and another supplemented with carvacrol, thymol, citral and EDTA. D...

Background: Describe characteristics of self-medication of the population, in the context of the COVID 19 pandemic. Material and Methods: We carried out a cross-sectional survey with students in a major public Peruvian university. We measured perception of self-medication of the population, as well as characteristics, consequences, and associated factors. Results: A total of 274 students of Pharmacy and biochemistry filled in the questionnaire, 80.3% of which reported to know someone that self-medicated during the COVID-19 pandemic. 98.9 % of surveyed participants considered that the current pandemic increased self-medication practices in the population and that it occurred more frequently when people have symptoms associated with COVID-19 (65.4%). The medicines most frequently used were ivermectin (79.2%), azithromycin (71.2%) and hydroxychloroquine (38.7%). Conclusion: According to the...