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artículo

Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice

Publicado por
Amador, Catalina, Bouska, Alisa, Wright, George, Weisenburger, DD, Feldman, AL, Greiner, TC, Lone, W, Heavican, T, Smith, L, Pileri, S, Tabanelli, V, Ott, G, Rosenwald, A, Savage, KJ, Slack, G, Kim, Won Seog, Hyeh, Y, Li, Y, Dong, G, Song, J, Ondrejka, S, Cook, James R, Barrionuevo, C, Lim, ST, Ong, CK, Chapman, J, Inghirami, G, Raess, PW, Bhagavathi, S, Gould, Clare, Blombery, Piers, Jaffe, Eliane, Morris, SW, Rimsza, LM, Vose, JM, Staudt, L, Chan, WC, Iqbal, J

Publicado 2022

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PURPOSE Peripheral T-cell lymphoma (PTCL) includes heterogeneous clinicopathologic entities with numerous diagnostic and treatment challenges. We previously defined robust transcriptomic signatures that distinguish common PTCL entities and identified two novel biologic and prognostic PTCL-not otherwise specified subtypes (PTCL-TBX21 and PTCL-GATA3). We aimed to consolidate a gene expression-based subclassification using formalin-fixed, paraffin-embedded (FFPE) tissues to improve the accuracy and precision in PTCL diagnosis. MATERIALS AND METHODS We assembled a well-characterized PTCL training cohort (n = 105) with gene expression profiling data to derive a diagnostic signature using fresh-frozen tissue on the HG-U133plus2.0 platform (Affymetrix, Inc, Santa Clara, CA) subsequently validated using matched FFPE tissues in a digital gene expression profiling platform (nCounter, NanoString Te...