In SARS-CoV-2 virus infection, HIF-1 overexpression drives a glycolysis-dependent metabolic change for increased cell proliferation and cytokine synthesis in various cells and tissues; Furthermore, due to the insufficient amount of ATP, various metabolic pathways that induce hyperglycemia are accelerated; an indicator of poor prognosis and high mortality in patients without a previous diagnosis of diabetes. Hyperglycemia is the result of oxidative stress-induced insulin resistance and increased glycolysis, as well as dysregulation of hormones such as glucagon, growth hormone, glucocorticoids, and insulin; whose synthesis decreases due to the transdifferentiation of beta cells. These hyperglycemic and hypoglycemic conditions have been associated, in COVID-19 patients, with new-onset diabetes, cardiomyocyte damage, and other cardiac problems with lung deterioration; as well as the presence...

La tuberculosis (TB) multisistémica, frecuentemente debido a la diseminación de Mycobacterium tuberculosis por vía linfohematógena durante la infección primaria y postprimaria, es una enfermedad rara en pacientes inmunocompetentes. Presentamos el caso de una paciente femenina de 29 años con diagnóstico de TB ganglionar en tratamiento que acude al servicio de emergencia del Hospital Regional Docente de Trujillo (HRDT) por presentar sintomatología compatible con TB pulmonar y pleural. El objetivo de este artículo es presentar el caso por su inusual evolución y exámenes de laboratorio que demuestran inmunocompetencia de la paciente a pesar de la presentación clínica.