Nanoscience and technology have enabled better insights into the environmental and health impacts arising from the mining, production and use of fossil and mineral fuels. Here we provide an overview of the nanoscience-based applications and discoveries concerning coal and mineral fuel (i.e., uranium-containing minerals) mining, refining/production, use, and disposal of wastes. These processes result in massive nanoparticle release and secondary nanoparticle generation which have highly significant environmental implications and human health consequences on local, regional, and even global levels. Until recently, very little was known about nanoparticle fractions. Recent advancements and sophistications enable us to detect, collect and study these materials which are roughly 1 nm (0.001 µm) up to several tens of nanometers in size. These materials are known to behave differently (chemica...