1
tesis de grado
Publicado 2024
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Small and medium-sized companies seek to improve and innovate in all their different processes, since there is more competition, and they all seek to be leaders in the sector in which they operate. However, a problem that involves the entire distribution chain, as well as the profitability of the business, is the return of merchandise. The main objective of this research study was to propose an improvement proposal in distribution management to enhance the number of returns in a wholesale company for the traditional channel using the SMED, Lean Six Sigma and Demand Forecasting. The secondary objectives of this implementation were to analyze and understand the root causes of this problem to address it in the best possible way using diagnostic tools such as the Pareto Diagram and Value Stream Mapping. Likewise, to quantify and measure the impact of this indicator within the company through...
2
artículo
Publicado 2019
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Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5-10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptib...