Among the organs that play important role in Carrion's disease, spleen occupies undoubtedly the first place. Thus, since the beginning of the disease, spleen combat anemia, which is the characteristic of this period, when the bone is still insufficient to repair the increasingly heavy losses desglobulizador process; is this body which defends, in large part, to the warty so frequent bacterial complications in this disease; and, finally, spleen, even though it seems paradoxical, the cause of death of the patient; either by colapsus of the viscera to the hematopoietic paper or septicemia which determines its embolizing their arteries claudication.

Upon completion of two hundred years of the birth of Hipólito Unanue, renews the Faculty of Medicine at the foot of bronze perpetuates the memory of the warm feelings of fervent admiration and gratitude that at all times she raised in the illustrious personality of the Father of the Peruvian Medicine Founder of the Medical and Founding father of national independence.

Text of the Conference supported by the University of San Agustin, Arequipa, August 2, 1954 Course Extension Post-Graduates.

The starting point of this work have been several cases of "fever of Carrion" in which a therapeutic purpose have made blood culture and with it, a vaccine that has been healing without the warty eruption occurs (have tried lately sick in Villar Clinic in July, with a surprising result.

Early laboratory work aimed at exclarecer Peruvian wart problem, started in 1897 by a group of medical students, among which occupies a prominent place loc Alberto Barton; enough to review publications in that year were to agree that that was the era of National Medicine, where he worked with great enthusiasm po lift the veil that hid Carrion's disease.