Infants with Autism Spectrum Disorder (ASD) need special therapies and tools to develop their skills. In many cases, these are not available due to socioeconomic factors, Picture Ex-change Communication System (PECS) is one of the most used tools due to its ease of use and good results. In this study we propose a methodology for developing a mobile application for interaction of infants with ASD with six phases, simultaneously we have created a technological tool called CMI, a mobile application for interaction of infants with ASD that adopts all the features of the traditional PECS and adding new functionalities. Twenty-five infants of varying severity participated in its implementation and received family support for more than a month. The results showed that there was an improvement of more than 15% in the preparation of materials, a reduction in the complexity of use and an increase ...