Background: COVID-19 is a virus that not only affects physical health, but also impacts people's psycho-emotional health and daily life, altering family, work, relationship, educational and learning dynamics, among many others. Objetive: This study sought to determine gender differences in terms of psycho-emotional impacts and experiences related to the COVID-19 pandemic in the adult population of the metropolitan area of Guadalajara, Mexico. Method: A qualitative study was implemented, with theory based on the data, through semi-structured interviews (ten women and three men) and through a non-probabilistic convenience sampling. Results: It stands out that the experience related to COVID-19 has generated negative emotions, couple conflicts and discomfort associated with the inability to carry out recreational activities. In the case of women, their routines...