Simulation and optimization was carried out using the CHEMCAD 5.2.0 program of an Ammonia Plant using Natural Gas as raw material. The objective of this project is to carry out the calculation and sizing of a plant for the production of 334,000 tons / year of ammonia, from natural gas as raw materials. Considering an average of 1000 tn / day (334 days) of operation of the plant, 41.6 tn / h of NH3 would be obtained, using the CHEMCAD program to determine the optimal variables in each stage. The ammonia produced will be used as raw material to produce fertilizers and other products. Five stages of the process were determined: Reform, Conversion, Purification, Metanation and Ammonia Loop. For each stage the optimum temperature and pressure of operation was determined using the program, as well as the balance of matter and energy in addition to the operation design of each equipment. In add...