Penile necrosis is a rare condition that may present in patients with diabetes mellitus or chronic kidney disease (CKD). The recommended treatment is controversial. We report a case of penile necrosis in a diabetic patient caused by episode of paraphimosis associated with uremic arteriopathy treated with partial amputation. Clinical Case: A 53-year-old male with a background of arterial hypertension, diabetes mellitus and CKD in hemodialysis. The patient presented with paraphimosis and glans necrosis. An emergency circumcision was carried out. A doppler ultrasound found fluid collection in the left corpus cavernosum, parietal vascular calcifications and vascular insufficiency in the corpus cavernosum that suggested necrosis. A partial amputation of the penis was carried out. After three years of follow-up, the outcome has remained favorable.

Loxoscelism is the clinical problem produced by the bite of a spider of the genus Loxosceles. The most severe presentation is systemic loxoscelism that can compromise the patient’s life if itis not diagnosed and treated in time. There are no reports about how it presents in patients with an epilepsy diagnosis. We present the case of a 28-year old male patient, with a prior history of epilepsy in treatment with anticonvulsants. He developed systemic loxoscelism after a spider bite in the posterior middle third of the right arm. However, the patient did not develop seizures despite the unfavourable course of his clinical symptoms.